Calcium ion sensor Case12

- High dynamic range calcium indicator
- Direct expression in cells
- High selectivity and sensitivity
- High brightness of fluorescent response
- Fast maturation at 37°C
- Relatively high pH stability
- Recommended for monitoring change of calcium concentration inside living cells

Available variants and fusions

Case12 codon usage is optimized for high expression in mammalian cells [Haas et al., 1996], but it can be successfully expressed in other heterological systems.

Case12-Cyto variant is localized in cell cytosol.