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Calcium ion sensor Case12
- High dynamic range calcium indicator
- Direct expression in cells
- High selectivity and sensitivity
- High brightness of fluorescent response
- Fast maturation at 37°C
- Relatively high pH stability
- Recommended for monitoring change of calcium concentration inside living cells
Protein description | Case12 is a high dynamic range genetically encoded fluorescent sensor for detection of intracellular Ca2+ changes [Souslova et al., 2007]. The sensor allows direct measurement of changes of calcium concentration in a physiological range from hundred nanomoles to micromoles with a high signal-to-noise ratio. Binding of Ca2+ is fast and reversible, allowing monitoring high-frequency-Ca2+ oscillations. In response to Ca2+ concentration rise, Case12 shows up to 12-fold increase of fluorescence brightness. Fluorescence of Case12 is characterized by single excitation/emission maxima peaked at 491/516 nm.
Case12 is recommended for monitoring change of calcium concentration inside living cells during various physiological and pathological conditions. |
Related products| PRODUCT | CAT.# | DESCRIPTION | SIZE | PRICE | The price does not include delivery. The price varies in different countries. Please contact your local distributor for exact prices and delivery information.
The product is not available in certain countries. Please contact Evrogen or your local distributor before ordering. |
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| Case12 expression/source vector |
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| pCase12-Cyto | FP991 | Mammalian expression vector allowing Case12 expression in cytosol under the control of CMV promoter | 20 μg | € 600.00 |
References:
- Souslova EA, Belousov VV, Lock J, Stromblad S, Kasparov S, Bolshakov AP, Pinelis VG, Labas YA, Lukyanov S, Mayr LM, Chudakov DM. Single fluorescent protein-based Ca2+ sensors with increased dynamic range. BMC Biotechnol. 2007; 7 (1):37. / pmid: 17603870
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